International Collaborative Partner of UTAR Global Research Network



Name Prof Dong-Yan Jin
Designation Clare and Lawrence Fok Professor in Precision Medicine (Endowed Professor)
Qualification Doctor of Medical Science (醫學博士), Chinese Academy of Preventive Medicine, Beijing (1991)

Bachelor of Science, Department of Biochemistry, College of Life Sciences, Sun Yatsen University, Guangzhou (1986)
Organization The University of Hong Kong
Email dyjin@hku.hk
Tel No. 852-39179491
Fax No. 852-28551254
URL http://www.sbms.hku.hk/staff/dong-yan-jin
UTAR Contact Person Prof Dr Lim Yang Mooi


Employment

 

1991-1994

Assistant and Associate Investigator, State Key Laboratory for Molecular Virology, Beijing, China

1994-1999

Fogarty Postdoctoral Fellow, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland, USA

1999-2010

Assistant and Associate Professor, Department of Biochemistry, The University of Hong Kong, Hong Kong

2010-date

Professor, Department of Biochemistry / School of Biomedical Sciences, The University of Hong Kong, Hong Kong

2016-date

Clara and Lawrence Fok Professor in Precision Medicine, The University of Hong Kong, Hong Kong

Teaching & Administration

  • Associate Dean (Internationalization and Partnership), Graduate School
  • Deputy Director, State Key Laboratory for Liver Research
  • Coordinator, BIOC2306: Molecular Medicine
  • Coordinator, BBMS4001: Final-Year Project
  • Member, MBBS II Hematology and Immunology System Block Planning Group
  • Member, Curriculum Committee of BSc Biochemistry Major

Teaching Interests

  • Molecular medicine
  • Advanced biochemistry
  • Advanced techniques in biochemistry and molecular biology
  • Teaching of biochemistry, genetics, microbiology and molecular cell biology to medical students

Research Interests

  • Viral oncogenesis (HTLV-1, hepatitis B virus and Epstein-Barr virus)
  • Innate antiviral response
  • Cell signaling

Awards & Honours

1992     Chinese Academy of Preventive Medicine Award for Excellence in Research and Development

1993  National Award for Outstanding Young Medical Scientists (中國首屆中青年醫學科技之星), jointly presented by Ministry of Health of China and Chinese Medical Association

1994  (U.S.) National Institutes of Health (NIH) John E. Fogarty Postdoctoral Visiting Fellow Award (1994-1999), John E. Fogarty International Center, National Institutes of Health

2001 Leukemia and Lymphoma Society (formerly Leukemia Society of America) Scholar Award

2001 (China) National Natural Science Award (國家自然科學獎), presented by the State Council

2002   Global Health Research Initiative Program New Foreign Investigator Award, presented by Fogarty International Center, (U.S.) National Institutes of Health

2008  Outstanding Researcher Award, presented by the University of Hong Kong

2013   Croucher Senior Research Fellowship (Croucher Award) 2014-2015, presented by the Croucher Foundation

2014 Outstanding Research Student Supervisor Award 2015-2016, presented by the University of Hong Kong

Selected Publications

 ·                 Total number of peer-reviewed articles in international journals: over 175

 ·                 H index: 47 by Scopus and Thomson Rheuters

·                 Citation ranking by Essential Science IndicatorsSM of Thomson Reuters: top 1% in “Biology and Biochemistry” and “All Fields”

 1.                  Jin, D.-Y., Li, Z.-L., Jin, Q., Yuwen, H. and Hou, Y.-D.: Vaccinia virus hemagglutinin: A novel member of the immunoglobulin superfamily. J. Exp. Med., 170(2):571-576, 1989.

2.                  Jin, D.-Y., Lyu, M.-S., Kozak, C. A. and Jeang, K.-T.: Functions of 14-3-3 proteins. Nature, 382(6589):308, 1996.

3.                  Wang, H.-L. and Jin, D.-Y.: Prevalence and genotype of hepatitis G virus in Chinese professional blood donors and hepatitis patients. J. Inf. Dis., 175(5):1229-1233, 1997.

4.                  Jin, D.-Y. and Jeang, K.-T.: HTLV-I Tax self-association in optimal trans-activation function. Nucl. Acids Res., 25(2):379-388, 1997.

5.                  Wang, H.-L., Yan, Z.-Y. and Jin, D.-Y.: Reanalysis of published DNA sequence amplified from Cretaceous dinosaur egg fossil. Mol. Biol. Evol., 14(5):589-591, 1997.

6.                  Jin, D.-Y. and Jeang, K.-T.: Transcription activation and self-association in yeast: protein-protein dimerization as a pleiotropic mechanism of HTLV-1 Tax function. Leukemia, 11(S3):3-6, 1997.

7.                  Jin, D.-Y., Teramoto, H., Giam, C.-Z., Chun, R.F., Gutkind, J.S. and Jeang, K.-T.: A human suppressor of c-Jun N-terminal kinase 1 (JNK1)-activation by tumor necrosis factor a.  J. Biol. Chem., 272(41):25816-25823, 1997. 

8.                  Wang, H.-L., Hou, Y.-D. and Jin, D.-Y.: Identification of a single genotype of hepatitis G virus by comparison of one complete genome from a healthy carrier with eight from patients with hepatitis. J. Gen. Virol., 78(12):3247-3253, 1997.

9.                  Jin, D.-Y., Chae, H.Z., Rhee, S.G. and Jeang, K.-T.: Regulatory role for a novel human thioredoxin peroxidase in NF-kB activation. J. Biol. Chem., 272(49): 30952-30961, 1997.

10.              Neuveut, C., Jin, D.-Y., Semmes, O.J., Diella, F., Callahan, R. and Jeang, K.-T.: Divergent subcellular locations of HTLV-Tax and Int-6: A contrast between in vitro protein-protein binding and intracellular protein colocalization. J. Biomed. Sci., 4(5):229-234, 1997. 

11.              Jin, D.-Y., Spencer, F. and Jeang, K.-T.:  Human T-cell leukemia virus type I oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell, 93(1): 81-91, 1998. 

12.              DeValck*, D., Jin*, D.-Y., Heyninck, K., Van de Craen, M., Contreras, R., Fiers, W., Jeang, K.-T. and Beyaert, R.: The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases.  Oncogene, 18(29): 4182-4190, 1999. (*equal first authors)

13.              Jin, D.-Y., Giordano, V., Kibler, K.V., Nakano, H. and Jeang, K.-T.: Role of adapter function in oncoprotein-mediated activation of NF-kB: Human T-cell leukemia virus type I Tax interacts directly with IkB kinase g. J. Biol. Chem., 274(25): 17402-17405, 1999.

14.              Jin, D.-Y., Wang, H.-L., Zhou, Y., Chun, A.C.S., Kibler, K.V., Hou, Y.-D., Kung, H.-f. and Jeang, K.-T.: Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation. EMBO J., 19(4):729-740, 2000.

15.              Zhou,Y., Kok, K.H., Chun, A.C.S., Wong, C.M., Wu, H.W., Lin, M.C.M., Fung, P.C.W., Kung, H.-f. and Jin, D.-Y.: Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced apoptosis. Biochem. Biophys. Res. Commun., 268(3):921-927, 2000.

16.              Wong, C.-M., Chun, A.C.S., Kok, K.H., Zhou, Y., Fung, P.C.W., Kung, H.-F., Jeang, K.-T. and Jin, D.Y.: Characterization of human and mouse peroxiredoxin (Prx) IV: evidence for inhibition by Prx-IV of epidermal growth factor- and p53-induced reactive oxygen species. Antioxidants and Redox Signaling, 2(3):507-518, 2000.

17.              Chun, A.C.S., Zhou, Y., Wong, C.-M., Kung, H.F., Jeang, K.-T. and Jin, D.Y.: Coiled-coil motif as a structural basis for the interaction of HTLV type 1 Tax with cellular cofactors. AIDS Res. Hum. Retrov., 16(16):1689-1694, 2000.  

18.              Zhou, H.-J., Wong, C.-M., Chen, J.-H., Qiang, B.-Q., Yuan, J.-G. and Jin, D.-Y.: Inhibition of LZIP-mediated transcription through direct interaction with a novel host cell factor-like protein. J. Biol. Chem., 276(31):28933-28938, 2001 (doi: 10.1074/jbc.M103893200).

19.              Ching, Y.-P., Zhou, H.-J., Yuan, J.G., Qiang, B.-Q., Kung, H.-F. and Jin, D.-Y.: Identification and characterization of FTSJ2, a novel human nucleolar protein homologous to bacterial ribosomal RNA methyltransferase. Genomics, 79(1): 2-6, 2002 (doi:10.1006/geno2001.6670).

20.              Wong, C.-M., Zhou, Y., Ng, R.W.M., Kung, H.-F. and Jin, D.-Y.: Cooperation of yeast peroxiredoxins Tsa1p and Tsa2p in the cellular defense against oxidative and nitrosative stress. J. Biol. Chem., 277(7): 5385-5394, 2002 (doi: 10.1074/ jbc.M106846200).

21.              Zhou, Y., Ching, Y.-P., Kok, K.H., Kung, H.-F. and Jin, D.-Y.: Post-transcriptional suppression of gene expression in Xenopus by small interfering RNA. Nucl. Acids Res., 30(7): 1664-1669, 2002.

22.              Wong, C.-M., Ching, Y.-P., Zhou, Y., Kung, H.-f. and Jin, D.-Y.: Transcriptional regulation of yeast peroxiredoxin gene TSA2 through Hap1p, Rox1p and Hap2/3/5p. Free Rad. Biol. Med., 34(5): 585-597, 2003.

23.              Ching, Y.-P., Wong, C.-M., Chan, S.-F., Leung, T. H.-Y., Ng, D. C.-H., Jin*, D.-Y. and Ng*, I. O.-l.: Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma. J. Biol. Chem., 278(12): 10824-10830, 2003 (doi: 10.1074/jbc. M208310200; *corresponding).

24.              Zhou, Y., Ching, Y.-P., Chun, A.C.S. and Jin, D.-Y.: Nuclear localization of the cell cycle regulator CDH1 and its regulation by phosphorylation. J. Biol. Chem., 278(14): 12530-12536, 2003 (doi: 10.1074/jbc.M212853200).

25.              Chun, A.C.S. and Jin, D.-Y.: Transcriptional regulation of mitotic checkpoint gene MAD1 by p53. J. Biol. Chem., 278(39): 37439-37450, 2003 (doi: 10.1074/ jbc.M307185200).

26.              Wong, C.-M., Siu, K.-L. and Jin, D.-Y.: Peroxiredoxin-null yeast cells are hypersensitive to oxidative stress and genomically unstable. J. Biol. Chem., 279(22): 23207-23213, 2004 (doi: 10.1074/jbc.M402095200).

27.              Ching, Y.-P., Chun, A.C.S., Chin, K.-T., Zhang, Z.-Q., Jeang, K.-T. and Jin, D.-Y.: Specific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complex. Retrovirology, 1:18, 2004 (doi: 10.1186/1742-4690-1-18; accompanied by a commentary).

28.              Chin, K.-T., Zhou, H.-J., Wong, C.-M., Lee, J.M.-F., Chan, C.-P., Qiang, B.-Q., Yuan, J.-G., Ng, I.O.-L. and Jin, D.-Y.: The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma. Nucl. Acids Res., 33(6):1859-1873, 2005 (doi: 10.1093/nar/gki332).

29.              Ching, Y.-P., Chan, S.-F., Jeang, K.-T. and Jin, D.-Y.: Retroviral oncoprotein Tax targets coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication. Nat. Cell Biol., 8(7):717-724, 2006 (doi: 10.1038/ncb1432).

30.              Siu, Y.-T., Chin, K.-T., Siu, K.-L., Choy, E.Y.W., Jeang, K.-T. and Jin, D.-Y.: TORC1 and TORC2 coactivators are required for Tax activation of the human T-cell leukemia virus type 1 long terminal repeats. J. Virol., 80(14):7052-7059, 2006 (doi: 10.1128/JVI.00103-06).

31.              Chan, C.-P., Siu, K.-L., Chin, K.-T., Yuen, K.-Y., Zheng, B. and Jin, D.-Y.: Modulation of the unfolded protein response by severe acute respiratory syndrome coronavirus spike protein. J. Virol., 80(18):9279-9287, 2006 (doi: 10.1128/JVI. 00659-06).

32.              Chin, K.-T., Chun, A.C.S., Ching, Y.-P., Jeang, K.-T. and Jin, D.-Y.: Human T-cell leukemia virus oncoprotein Tax represses nuclear receptor-dependent transcription by targeting coactivator TAX1BP1. Cancer Res., 67(3):1072-1081, 2007 (doi: 10.1158/0008-5472.CAN-06-3053).

33.              Kok, K.H., Ng, M.-H.J., Ching, Y.-P. and Jin, D.-Y.: Human TRBP and PACT interact with each other and associate with Dicer to facilitate the production of small interfering RNA. J. Biol. Chem., 282(24):17649-17657, 2007 (doi: 10.1074/ jbc.M611768200).

34.              Siu, Y.-T. and Jin, D.-Y.: CREB - a real culprit in oncogenesis. FEBS J., 274 (13):3224-3232, 2007 (doi: 10.1111/j.1742-4658. 2007.05884.x; one of the top ten most-cited FEBS Journal papers two years from publication).

35.              Choy, E.Y.-W., Siu, K.-L., Kok, K.-H., Lung, R.W.-M., Tsang, C.M., To, K.-F., Kwong, D.L.-W., Tsao, S.W. and Jin, D.-Y.: An Epstein-Barr virus-encoded microRNA targets PUMA to promote host cell survival. J. Exp. Med., 205(11): 2551-2560, 2008 (doi: 10.1084/jem.20072581).

36.              Siu, Y.-T., Ching, Y.-P. and Jin, D.-Y.: Activation of TORC1 transcriptional coactivator through MEKK1-induced phosphorylation. Mol. Biol. Cell, 19(11): 4750-4761, 2008 (doi: 10.1091/mbc.E08-04-0369).

37.              Siu, K.-L., Kok, K.-H., Ng, M.-H.J., Poon, V.K.M., Yuen, K.-Y., Zheng, B.-J. and Jin, D.-Y.: Severe acute respiratory syndrome coronavirus M protein inhibits type I interferon production by impeding the formation of TRAF3×TANK×TBK1/IKKe complex. J. Biol. Chem., 284(24):16202-16209, 2009 (doi: 10.1074/ jbc.M109.008227).

38.              Tang, H.-M.V., Siu, K.-L., Wong, C.-M. and Jin, D.-Y.: Loss of yeast peroxiredoxin Tsa1p induces genome instability through activation of DNA damage checkpoint and elevation of dNTP levels. PLoS Genet., 5(10):e1000697, 2009 (doi: 10.1371/journal.pgen.1000697).

39.              Wong, C.-M., Tang, H.-M.V., Kong, K.-Y.E., Wong, G.-W.O., Qiu, H., Jin, D.-Y. and Hinnebusch, A.G.: Yeast arginine methyltransferase Hmt1p regulates transcription elongation and termination by methylating Npl3p. Nucl. Acids Res., 38(7):2217-2228, 2010 (doi: 10.1093/nar/gkp1133).

 

40.              Chan, C.-P., Mak, T.-Y., Chin, K.-T., Ng, I. O.-L. and Jin, D.-Y.: N-linked glycosylation is required for optimal proteolytic activation of membrane-bound transcription factor CREB-H. J. Cell Sci., 123(9):1438-1448, 2010 (doi: 10.1242/ jcs.067819).

 

41.              Fomenko, D., Koc, A., Agisheva, N., Jacobsen, M., Kaya, A., Malinouski, M., Rutherford, J., Siu, K.-L., Jin, D.-Y., Winge, D. and Gladyshev, V.: Thiol peroxidases mediate specific genome-wide regulation of gene expression in response to hydrogen peroxide. Proc. Natl. Acad. Sci. USA, 108(7):2729-2734, 2011 (doi: 10.1073/pnas.1010721108).

42.              Kok, K.-H., Lui, P.-Y., Ng, M.-H.J., Siu, K.-L., Au, S.W.N. and Jin, D.-Y.: The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response. Cell Host Microbe, 9(4):299-309, 2011 (doi: 10.1016/j.chom.2011.03.007).

43.              Ng, M.-H.J., Ho, T.-H., Kok, K.-H., Siu, K.-L., Li, J. and Jin, D.-Y.: MIP-T3 is a negative regulator of innate type I interferon response. J. Immunol., 187(12):6473-6482, 2011 (doi: 10.4049/jimmunol.1100719).

44.              Lei, T., Siu, K.-L., Kok, K.-H., Chan, K.-H., Chan, E.Y.T., Hung, I.F.N., To, K.K.W., Li, P.C.K., Zhou, J., Zheng, B.-J., Yuen, K.-Y., Wang, M. and Jin, D.-Y.: Anti-ganglioside antibodies were not detected in human subjects infected with or vaccinated against 2009 pandemic influenza A (H1N1) virus. Vaccine, 30(16):2605-2610, 2012 (doi: 10.1016/j.vaccine.2012.02.009).

45.              Chun, A.C.-S., Kok, K.-H., and Jin, D.-Y.: REV7 is required for anaphase promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1. Cell Cycle, 12(2):365-378, 2013 (doi: 10.4161/cc.23214).

46.              Lei, T., Yuen, K.-S., Xu, R., Tsao, S.W., Chen, H., Li, M., Kok, K.-H., and Jin, D.-Y.: Targeting of DICE1 tumor suppressor by Epstein-Barr virus-encoded miR-BART3* microRNA in nasopharyngeal carcinoma. Int. J. Cancer, 133(1):79-88, 2013 (doi: 10.1002/ijc.28007).

47.              Tang, H.-M.V., Gao, W.-W., Chan, C.-P., Siu, Y.-T., Wong, C.-M., Kok, K.-H., Ching, Y.-P., Takemori, H., and Jin, D.-Y.: LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription. Retrovirology, 10:40, 2013 (doi: 10.1186/1742-4690-10-40).

48.              Chan, C.-P., Siu, Y.-T., Kok, K.-H., Ching, Y.-P., Tang, H.-M.V., and Jin, D.-Y.: Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats. Retrovirology, 10:47, 2013 (doi: 10.1186/1742-4690-10-47).

49.              Chan, C.-P., Kok, K.-H., Tang, H.-M.V., Wong, C.-M., and Jin, D.-Y.: Internal ribosome entry site-mediated translational regulation of ATF4 splice variant in mammalian unfolded protein response. Biochim. Biophys. Acta – Mol. Cell Res., 1833(10):2165-2175, 2013 (doi: 10.1016/j.bbamcr.2013.05.002).

50.              Jin, D.-Y., Shi, Y.-B., and Wu,T.-C.: In memoriam: Kuan-Teh Jeang, MD PhD (1958-2013). Cell Biosci., 3:13, 2013 (doi: 10.1186/2045-3701-3-13).

51.              Kok, K.-H., Tang, H.-M.V., and Jin, D.-Y.: “One Health” for the people of Hong Kong and the world. Sci. China Life Sci., 59(10):1068-1070, 2016 (doi: 10.1007/s11427-012-4408-6).

52.              Kok, K.-H., and Jin, D.-Y.: Balance of power in host-virus arms races. Cell Host Microbe, 14(1):5-6, 2013 (doi: 10.1016/j.chom.2013.07.004).

53.              Lei, T., Yuen, K.-S., Tsao, S.W., Chen, H., Kok, K.H., and Jin, D.-Y.: Perturbation of biogenesis and targeting of Epstein-Barr virus-encoded miR-BART3 microRNA by A-to-I editing. J. Gen. Virol., 94(12):2739-2744, 2013 (doi: 10.1099/ vir.0.056226-0).

54.              Kew, C., Lui, P.-Y., Chan, C.-P., Liu, X., Au, S.W.N., Mohr. I., Jin*, D.-Y., and Kok*, K.-H.: Suppression of PACT-induced type I interferon production by herpes simplex virus type 1 Us11 protein. J. Virol., 87(24):13141-13149, 2013 (doi: 10.1128/JVI02564-13; *:corresponding).

55.              Kong, K.-Y.E., Tang, H.-M.V., Pan, K., Huang, Z., Lee, T.-H.J., Hinnebusch, A., Jin*, D.-Y., and Wong*, C.-M.: Cotranscriptional recruitment of yeast TRAMP complex to intronic sequences promotes optimal pre-mRNA splicing. Nucl. Acids Res., 42(1):643-660, 2014 (doi: 10.1093/nar/gkt888; *: corresponding).

56.              Siu, K.-L., Chan, C.-P., Woo, P.C.-Y., and Jin, D.-Y.: Comparative analysis of the activation of unfolded protein response by spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus HKU1. Cell Biosci., 4:3, 2014 (doi: 10.1186/2045-3701-4-3).

57.              Siu, K.-L., Chan, C.-P., Kok, K.-H., Woo, P.C.-Y., and Jin, D.-Y.: Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain. Cell. Mol. Immunol., 11(2):141-149, 2014 (doi: 10.1038/cmi.2013.133).

58.              Siu, K.-L., Yeung, M.-L., Kok, K.-H., Yuen, K.-S., Kew, C., Lui, P.-Y., Chan, C.-P., Tse, H., Woo, P.C.Y., Yuen, K.-Y., and Jin, D.-Y.: Middle East respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in innate antiviral response. J. Virol., 88(9):4866-4876, 2014 (doi: 10.1128/JVI03649-13).

59.              Tang, H.-M.V., Gao, W.-W., Chan, C.-P., Cheng, Y., Chaudhary, V., Deng, J.-J., Yuen, K.-S., Wong, C.-M., Ng, I.O.-L., Kok, K.-H., Zhou, J., and Jin, D.-Y.: Requirement of CRTC1 coactivator for hepatitis B virus transcription. Nucl. Acids Res., 42(20):12455-12468, 2014 (doi: 10.1093/nar/gku925).

60.              Yuen, K.-S., Chan, C.-P., Wong, N.-H.M., Ho, C.-H., Ho, T.-H., Lei, T., Deng, W., Tsao, S.W., Chen, H., Kok, K.-H., and Jin, D.-Y.: CRISPR/Cas9-mediated genome editing of Epstein-Barr virus in human cells. J. Gen. Virol., 96(3):626-636, 2015 (doi: 10.1099/jgv.0.000012).

61.              Tang, H.-M.V., Pan, K., Kong, K.-Y.E., Hu, L., Chan, L.-C., Siu, K.-L., Sun, H., Wong, C.-M., and Jin, D.-Y.: Loss of APD1 in yeast confers hydroxyurea sensitivity suppressed by Yap1p transcription factor. Sci. Rep., 5:7897, 2015 (doi: 10.1038/srep07897).

62.              Tang, H.-M.V., Gao, W.-W., Chan, C.-P., Cheng, Y., Deng, J.-J., Yuen, K.-S., Iha, H., and Jin, D.-Y.: SIRT1 suppresses human T-cell leukemia virus type 1 transcription. J. Virol., 89(16):8623-8631, 2015 (doi: 10.1128/JVI.01229-15).

63.              Ho, T.-H., Kew, C., Lui, P.-Y., Chan, C.-P., Satoh, T., Akira, S., Jin*, D.-Y., and Kok*, K.-H.: PACT- and RIG-I-dependent activation of type I interferon production by a defective-interfering RNA in measles virus vaccine. J. Virol., 90(3):1557-1568, 2016 (doi: 10.1128/JVI.02161-15; *: corresponding).

64.              Yuen, C.-K., Chan, C.-P., Fung, S.-Y., Wang, P.-H., Tang, H.-M.V., Yuen, K.-S., Chan, C.-P., Jin*, D.-Y. and Kok*, K.-H.: Suppression of type I interferon production by human T-cell leukemia virus type 1 oncoprotein Tax through inhibition of IRF3 phosphorylation. J. Virol., 90(8):3902-3912, 2016 (doi: 10.1128/JVI.00129-16; *: corresponding).

65.              Chaudhary, V., Zhang, S., Yuen, K.-S., Li, C., Lui, P.-Y., Fung, S.-Y., Wang, P.-H.,  Chan, C.-P., Li, D.,  Kok, K.-H., Liang*, M., and Jin*, D.-Y.: Suppression of type I and type III interferon signalling by NSs protein of severe fever-with-thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation. J. Gen. Virol., 96(11):3204-3211, 2015 (doi: 10.1099/jgv. 0.000280; *: corresponding).

66.              Lui, P.-Y., Jin, D.-Y., and Stevenson N.J.: MicroRNA: master controllers of intracellular signalling pathways. Cell. Mol. Life Sci., 72(18):3531-3542, 2015 (doi: 10.1007/s00018-015-1940-0).

67.              Cheng, Y., Gao, W.-W., Tang, H.-M.V., Deng, J.-J., Wong, C.-M., Chan*, C.-P., and Jin*, D.-Y.: β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H. Sci. Rep., 6:23938, 2016 (doi: 10.1038/srep23938; *: corresponding).

68.              Lui, P.-Y., Wong, L.-Y. R., Fung, C.-L., Siu, K.-L., Yeung, M.-L., Yuen, K.-S., Chan, C.-P., Woo, P. C.-Y., Yuen, K.-Y., and Jin, D.-Y.: Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through inhibition of TBK1-dependent phosphorylation of IRF3. Emerg. Microbes Infect., 5:e39, 2016 (doi: 10.1038/emi.2016.33).

69.              Zhao, H., Zhou, J., Zhang, K., Chu, H., Liu, D., Poon, V.K., Chan, C.C., Leung, H.C., Fai, N., Lin, Y.P., Zhang, A.J., Jin, D.-Y., Yuen, K.Y., and Zheng, B.J.: A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses. Sci. Rep., 6:22008, 2016 (doi: 10.1038/srep22008).

70.              Deng, J.-J., Kong, K.-Y.E., Gao, W.-W., Tang, H.-M.V., Chaudhary, V., Cheng, Y., Zhou, J., Chan, C.-P., Wong, D.K.-H., Yuen, M.-F., and Jin, D.-Y.: Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription. Biochim. Biophys. Acta – Gene Regulatory Mechanisms, 1860(4):491-501, 2017 (doi: 10.1016/j.bbagrm.2017.02.007).

71.              Lui, P.-Y., Wong, L.-Y.R., Ho, T.-H., AU, S.W.N., Chan, C.-P., Kok, K.-H., and Jin, D.-Y.: PACT facilitates RNA-induced activation of MDA5 by promoting MDA5 oligomerization. J. Immunol., 199(5):1846-1855, 2017 (doi: 10.4049/jimmunol. 1601493).

72.              Chaudhary, V., Yuen, K.-S., Chan, J.F.-W., Chan, C.-P., Wang, P.-H.,  Cai, J.-P., Zhang, S., Liang, M.,  Kok, K.-H., Chan, C.-P., Yuen, K.-Y., and Jin, D.-Y.: Selective activation of type II interferon signaling by Zika virus NS5 protein. J. Virol., 91(14):e00163-17, 2017 (doi: 10.1128/JVI.00163-17).

73.              Chan, C.-P., Yuen, C.-K., Fung, S.-Y., Cheung, P.-H.H., Lui, P.-Y., Chen, H., Kok, K.-H., and Jin, D.-Y.: Antiviral activity of double-stranded RNA-binding protein PACT against influenza A virus mediated through suppression of viral RNA polymerase. FASEB J., 32(8):4380-4393, 2018 (doi: 10.1096/fj.201701361R).

74.              Yuen, K.-S., Wang, Z.-M., Wong, N.-H.M., Zhang, Z.-Q., Cheng, T.-F., Lui, W.-Y., Chan, C.-P., and Jin, D.-Y.: Suppression of Epstein-Barr virus DNA load in latently infected nasopharyngeal carcinoma cells by CRISPR/Cas9. Virus Res., 244:296-303, 2018 (doi: 10.1016/j.virusres.2017.04.019).

75.              Chan, C.-P., Kok, K.-H. & Jin, D.-Y.: Human T-cell leukemia virus type 1 infection and adult T-cell leukemia. Adv. Exp. Med. Biol., 1018:147-166, 2017 (doi: 10.1007/978-981-10-5765-6_9).

76.              Cheung, P.-H.H., Chan, C.-P. & Jin, D.-Y.: To announce or not to announce: What is known about the 2016-2017 influenza season in Hong Kong? Emerg. Microbes Infect. 6:e78, 2017 (doi: 10.1038/emi.2017.76).

77.              Gao, W.-W., Tang, H.-M.V., Cheng, Y., Chan, Ching-P., Chan, Chi-P. & Jin, D.-Y.: Suppression of gluconeogenic gene transcription by SIK1-induced ubiquitination and degradation of CRTC1. Biochim. Biophys. Acta – Gene Regulatory Mechanisms, 1861(3):211-223, 2018 (doi: 10.1016/j.bbagrm.2018.01.021).

78.              Wang, P.-H., Fung, S.-Y., Gao, W.-W., Deng, J.-J., Cheng, Y., Chaudhary, V., Yuen, K.-S., Ho, T.-H., Chan, Ching-P., Zhang, Y., Kok, K.-H., Yang, W., Chan,         Chi-P. & Jin, D.-Y.: A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing. Nucl. Acids Res., 46(8):4054-4071, 2018 (doi: 10.1093/nar/gky186).

79.              Wang, P.-H., Deng, J.-J., Siu, K.-L., Gao, W.-W., Chaudhary, V., Cheng, Y., Fung, S.-Y., Yuen, K.-S., Ho, T.-H., Chan, Ching-P., Zhang, Y., Kok, K.-H., Yang, W,, Chan, Chi-P., & Jin, D.-Y.: Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16. EMBO Rep., 19(10):e45737, 2018 (doi: 10.15252/ embr.201845737; feathered on the October 2018 cover).

 

Professional Membership

1.            Lifetime Member, Society of Chinese Bioscientists in America (SCBA), since 1997

2.            Lifetime Full Member, American Society for Virology (ASV), since 1997

3.            External Member, Academic Committee, State Key Laboratory for Molecular Virology, 1999-2008

4.            Editorial Board Member, Chinese Journal of Experimental and Clinical Virology, since 2000

5.            Member, American Society for Microbiology (ASM), since 2000

6.            Member, China National Committee for Terms in Biochemistry and Molecular Biology, 2001-2011, 2018-2023

7.            Editorial Board Member, Chinese Journal of Virology, 2001-2016

8.            External Member, Microbiology Subject Panel, National Natural Science Foundation of China (NSFC), 2003

9.            Editorial Board Member, Retrovirology (an open access journal published by BioMed Central), since 2004

10.        Member, American Society for Cell Biology (ASCB), since 2005

11.        Managing Editor, Frontiers in Bioscience, since 2006

12.        Editorial Board Member, PLoS ONE, since 2006

13.        Editorial Board  Member, Chinese Journal of Biotechnology, since 2007

14.        Editorial Board member, Nucleic Acid Therapeutics, formerly known as Oligonucleotides, since 2009

15.        Deputy Editor-in-Chief, Cell and Bioscience, since 2010

16.        International Editorial Board member, Journal of the Formosan Medical Association, since 2011

17.        Grant Review Board member, Hong Kong Health and Medical Research Fund (November 2013 to September 2019)

18.        Member, International Retrovirology Association, since 2013

19.        Member, International Association for Research on Epstein-Barr Virus and Associated Diseases (EBV Association), since 2014

20.        Editorial Board Member and Review Editor, Emerging Microbes and Infections, since 2015

21.        President, Hong Kong Society of Biochemistry and Molecular Biology, since 2017

22.        Deputy Editor-in-Chief, Chinese Journal of Biotechnology, since 2017

23.        Managing Guest Editor, Special Issue of Virus Research on “CRISPR-Cas Antiviral Strategies”, 2017-2018

24.        Guest Editor, Special Issue of Viruses on “Applications of CRISPR Technology in Virology 2018”, 2017-2018

25.        Editorial Board Member, Journal of Virology, 2019-2021

Professional Activities

August 1991-October 1993: Assistant Investigator (助理研究員), State Key Laboratory for Molecular Virology, Institute of Virology, Chinese Academy of Preventive Medicine, Beijing; Lecturer (dual position), Graduate School, Chinese Academy of Preventive Medicine, Beijing

November 1993-June 1994: Associate Investigator (副研究員), State Key Laboratory for Molecular Virology, Institute of Virology, Chinese Academy of Preventive Medicine, Beijing; Associate Professor (dual position), Graduate School, Chinese Academy of Preventive Medicine, Beijing

June 1994-January 1999: John E. Fogarty Postdoctoral Fellow, Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (with Dr. Kuan-Teh Jeang)

December 1998-December 1999: Research Officer, Institute of Molecular Biology, The University of Hong Kong, Hong Kong

December 1999-December 2001: Research Assistant Professor, Institute of Molecular Biology, The University of Hong Kong; Honorary Assistant Professor (secondary appointment), Department of Medicine, The University of Hong Kong

January 2002-June 2008: Assistant Professor, Department of Biochemistry, The University of Hong Kong

July 2008-June 2010: Associate Professor (Tenured), Department of Biochemistry, The University of Hong Kong

July 2010-date: Professor (Tenured), Department of Biochemistry/School of Biomedical Sciences, The University of Hong Kong

March 2016-date: Clara and Lawrence Fok Professor in Precision Medicine, The University of Hong Kong

Quarterly Activites
July - September 2018
  • Accepted as UTAR ICP
October - December 2018
  • Provide advice to PhD student on the CRIPR-Cas 9 Technology